Search results for " Sudden cardiac Death"

showing 9 items of 9 documents

Sudden cardiac death due to anomalous origin of the right coronary artery: A case report in a child

2006

medicine.medical_specialtyVascular diseasebusiness.industrySocio-culturaleContraction band necrosisAnomalous origin right coronary arterymedicine.diseaseSudden deathCoronary heart diseaseSudden cardiac deathSurgerySudden cardiac deathAnomalous origin right coronary artery; Contraction band necrosis; Sudden cardiac death; Coronary Vessel Anomalies; Death Sudden Cardiac; Fatal Outcome; Humans; Infant; Male; Myocardium; Necrosis; Sinus of Valsalva; Cardiology and Cardiovascular MedicineRight coronary arterymedicine.arteryInternal medicineCirculatory systemmedicineCardiologyCongenital diseaseSudden cardiac death; Anomalous origin right coronary artery; Contraction band necrosisCardiology and Cardiovascular MedicinebusinessContraction band necrosisInternational Journal of Cardiology
researchProduct

Comparison of Nonclassic and Classic Phenotype of Hypertrophic Cardiomyopathy Focused on Prognostic Cardiac Magnetic Resonance Parameters: A Single-C…

2022

Patients with nonclassic phenotypes (NCP)—more advanced stages of hypertrophic cardiomyopathy (HCM)—constitute an intriguing and heterogeneous group that is difficult to diagnose, risk-stratify, and treat, and often neglected in research projects. We aimed to compare cardiac magnetic resonance (CMR) parameters in NCP versus classic phenotypes (CP) of HCM with special emphasis given to the parameters of established and potential prognostic importance, including numerous variables not used in everyday clinical practice. The CMR studies of 88 patients performed from 2011 to 2019 were postprocessed according to the study protocol to obtain standard and non-standard parameters. In NCP, the late …

Clinical Biochemistrycardiovascular systemcardiovascular diseasesmagnetic resonance imaging; late gadolinium enhancement; hypertrophic cardiomyopathy; phenotype; sudden cardiac death; new imaging techniques; prognosis; outcomes; functional imaging; left ventricular obstruction; left atrium; mitral valve apparatusDiagnostics
researchProduct

SUDDEN UNEXPLAINED JUVENILE DEATH AND THE ROLE OF MEDICOLEGAL INVESTIGATION: UPDATE ON MOLECULAR AUTOPSY

2012

In the past few years, contributions of molecular biology assays to the investigation of sudden juvenile death have permitted to clarify some of the pathogenetic aspects of sud-den arrhythmic death, opening the way to preventive action on victims’ relatives. We reviewed literature on the genetics of sudden juvenile death, and on molecular biol-ogy assays performed on autoptic samples. Biological investigation permits the detection of genetic mutations underlying the suscep-tibility to sudden cardiac death of individuals with rare inherited forms of arrhythmia (Long QT Syndrome, Brugada Syndrome, Lev’s disease etc.) through the analysis of criti-cal sequences codifying for ion channel subuni…

Settore MED/43 - Medicina Legalemolecula autpsy sudden cardiac death
researchProduct

Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study

2021

The presented study evaluated the expression of dystrophin and MMP-9 in cases of sudden cardiac death (SCD) due to coronary atherosclerotic disease (CAD) in order to analyze the characteristics and the chronology of their expression, providing evidence on the possible role in post-mortem diagnosis of myocardial ischemia. The expression of these proteins was also compared to C5b-9 complex and fibronectin expression to evaluate any differences. Two groups of CAD-related SCD, respectively group 1 with gross and/or histological evidence and group 2 with no specific histological signs of myocardial ischemia, were used. A third group formed by cases of acute mechanical asphyxiation was used as a …

Pathologymedicine.medical_specialtyMyocardial ischemiaMyocardial IschemiaCoronary Artery DiseasePathology and Forensic MedicineSudden cardiac deathDystrophin; Immunohistochemistry; MMP-9; Myocardial ischemia; Post-mortem analysis; Sudden cardiac deathDystrophinmedicineHumansMetalloproteinasebiologybusiness.industryMyocardiummedicine.diseaseImmunohistochemistryStainingFibronectinIssues ethics and legal aspectsMatrix Metalloproteinase 9biology.proteinImmunohistochemistryAntibodyDystrophinbusiness
researchProduct

Immunohistochemical marker for Na+ CP type Vα (C-20) and heterozygous nonsense SCN5A mutation W822X in a sudden cardiac death induced by mild anaphyl…

2009

A sudden death likely due to mild anaphylactic reaction in a young man is described. Autoptic, histologic, immunohistochemical, and laboratory findings were strongly consistent with the diagnosis of a mild anaphylactic reaction. Genetic molecular analysis, performed on formalin-fixed, paraffin-embedded tissues, showed a mutation described as W822X in a family with electrocardiographic pattern typical of Brugada Syndrome. It results in a nonsense mutation generating a truncated form of the channel protein. The mutation is due to a point substitution of a guanine with an adenine residue (G2466A). Immunohistochemistry and laser scanning confocal microscopy on sections from heart formalin-fixed…

MaleChannellopathies; Confocal laser scanning microscopy; Immunohistochemistry; Na+ CP type Vα (C-20); Sodium channel; Sudden cardiac death; W822X; Adult; Anaphylaxis; Brugada Syndrome; Fatal Outcome; Humans; Male; Muscle Proteins; Myocardium; Myocytes Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Peanut Hypersensitivity; Sodium Channels; Death Sudden Cardiac; Mutation Missense; 2734; Medical Laboratory Technology; HistologyMuscle Proteinsmedicine.disease_causeSodium ChannelsSudden cardiac deathNAV1.5 Voltage-Gated Sodium ChannelNa+ CP type V[alpha] (C-20)Fatal OutcomeMissense mutationMyocytes CardiacConfocal laser scanning microscopyCP type Vα (C-20)Cellular localizationBrugada syndromeBrugada SyndromeMutationChemistrySodium channelChannellopathiesImmunohistochemistryChannellopathies; Confocal laser scanning microscopy; Immunohistochemistry; Na; +; CP type Vα (C-20); Sodium channel; Sudden cardiac death; W822XDeathMedical Laboratory TechnologyCardiologyCardiacAdultmedicine.medical_specialtyHistologyNa+ CP type V[alpha] (C-20) confocal laser scanning microscopy immunohistochemistry sodium channel channellopathies W822X sudden cardiac deathNonsense mutation2734Mutation MissenseSocio-culturaleNa+ CP type Vα (C-20)+Sudden deathPathology and Forensic MedicineInternal medicinemedicineHumansPeanut HypersensitivityNacardiovascular diseasesW822XAnaphylaxisMyocytesSodium channelMyocardiummedicine.diseaseMolecular biologySuddenSudden cardiac deathDeath Sudden CardiacMutationMissenseNa+ CP type V[alpha] (C-20); confocal laser scanning microscopy; immunohistochemistry; sodium channel; channellopathies; W822X; sudden cardiac death
researchProduct

In-Hospital and One-Year Outcomes of Patients after Early and Late Resuscitated Cardiac Arrest Complicating Acute Myocardial Infarction—Data fr…

2022

The prognostic role of early (less than 48 h) resuscitated cardiac arrest (ErCA) complicating acute myocardial infarction (AMI) is still controversial. The present study aimed to analyse the short-term and one-year outcomes of patients after ErCA and late resuscitated cardiac arrest (LrCA) compared to patients without cardiac arrest (CA) complicating AMI. Data from the prospective nationwide Polish Registry of Acute Coronary Syndromes (PL-ACS) were used to assess patients with resuscitated cardiac arrest (rCA) after AMI. Baseline clinical characteristics and the predictors of all-cause death were assessed. The all-cause mortality rate, complications, performed procedures, and re-hospitalisa…

cardiac rehabilitationsecondary prevention of sudden cardiac deathdiabetes mellitus; ejection fraction; heart failure; myocardial infarctionlife-threatening ventricular arrhythmiaRMedicineacute coronary syndrome; cardiac rehabilitation; sudden cardiac death; life-threatening ventricular arrhythmia; early and late cardiac arrest; secondary prevention of sudden cardiac deathGeneral Medicineearly and late cardiac arrestsudden cardiac deathacute coronary syndromeJournal of Clinical Medicine; Volume 11; Issue 3; Pages: 609
researchProduct

Prognostic Role of Late Gadolinium Enhancement in Patients With Hypertrophic Cardiomyopathy and Low-to-Intermediate Sudden Cardiac Death Risk Score

2019

Sudden cardiac death (SCD) is the most life-threating complication of hypertrophic cardiomyopathy. Guidelines of the European Society of Cardiology (ESC) suggest the implantation of an implantable cardioverter defibrillator in primary prevention according to a 5-year risk SCD score >= 6%. The aim of the study is to evaluate the prognostic role of late gadolinium enhancement (LGE) in patients with a 5-year risk SCD score <6%. In this multicenter study, we performed cardiac magnetic resonance in 354 consecutive hypertrophic cardiomy-opathy patients (257 males, range of age 54 +/- 17) with a risk SCD score <6% (302 with <4% and 52 with >= 4 and <6% risk). Hard cardiac events,…

Malemedicine.medical_treatmentLeftCardiomyopathyContrast MediaGadolinium030204 cardiovascular system & hematologyVentricular Function Left030218 nuclear medicine & medical imagingSudden cardiac death0302 clinical medicineRisk Factorshemic and lymphatic diseasesVentricular FunctionFramingham Risk Scoremedicine.diagnostic_testIncidenceHypertrophic cardiomyopathyMiddle AgedImplantable cardioverter-defibrillatorPrognosisMagnetic Resonance ImagingHypertrophic Cardiomyopathy Sudden Cardiac Death.DeathSurvival RateItalyCineCardiologyFemaleCardiology and Cardiovascular MedicineCardiaccongenital hereditary and neonatal diseases and abnormalitiesmedicine.medical_specialtyCardiomyopathyHeart VentriclesMagnetic Resonance Imaging CineRisk Assessment03 medical and health sciencesInternal medicinemedicineHumanscardiovascular diseasesRetrospective Studiesbusiness.industryMyocardiumMagnetic resonance imagingRetrospective cohort studyCardiomyopathy HypertrophicCardiomyopathy Hypertrophic; Contrast Media; Death Sudden Cardiac; Female; Follow-Up Studies; Gadolinium; Heart Ventricles; Humans; Incidence; Italy; Magnetic Resonance Imaging Cine; Male; Middle Aged; Myocardium; Prognosis; ROC Curve; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Ventricular Function Leftmedicine.diseaseSuddenSudden cardiac deathDeath Sudden CardiacROC CurveHypertrophicComplicationbusinessFollow-Up Studies
researchProduct

Myocardial bridge pathology and preventable accidents during physical activity of healthy subjects: A case report and a literature review.

2020

Myocardial bridging is a congenital coronary pathology described as a segment of coronary artery which courses through the myocardial wall under the muscle bridge. Although the prognosis of myocardial bridging is benign, sports medicine recognises myocardial bridging as a leading cause of sudden death among young basketball, football and soccer players. The authors report a case of a 42-year-old man who collapsed while playing football. He died notwithstanding prompt medical assistance and cardiopulmonary resuscitation. At autopsy, gross examination of the heart revealed the intramural course of the left anterior descending coronary artery to be 2 cm from its coronary ostial origin. Histol…

Myocardial bridgeAdultMalePathologymedicine.medical_specialtyPhysical activityPoison controlAutopsy030204 cardiovascular system & hematologyMyocardial bridge sudden cardiac death autopsy physical activity sportSudden cardiac death03 medical and health sciences0302 clinical medicineSettore MED/43 - Medicina LegaleInjury preventionMedicineHumans030212 general & internal medicineExercisebusiness.industryMyocardiumHealthy subjectsArrhythmias CardiacGeneral Medicinemedicine.diseasemedicine.anatomical_structureDeath Sudden CardiacItalybusinessArterySportsThe Medico-legal journal
researchProduct

Immunohistochemical detection of early myocardial infarction: a systematic review

2017

The postmortem diagnosis of early myocardial infarction is a challenge for forensic pathologists because the routine histology is neither specific. Many authors have suggested the use of the immunohistochemistry to fill the gaps in the histological diagnosis of early myocardial infarction. This review aims to analyse advances of immunohistochemical detection of early cardiac damage due to ischaemia. To this purpose, we reviewed experimental studies that investigated immunohistochemical markers and their estimated timing of expression. The review was performed according to specific inclusion and exclusion criteria, and a total of 23 studies assessing the immunohistochemical markers for the d…

Pathologymedicine.medical_specialty2734Myocardial InfarctionIschemia030204 cardiovascular system & hematologyPathology and Forensic MedicineSudden cardiac death03 medical and health sciences0302 clinical medicineSettore MED/43 - Medicina LegaleHistological diagnosisEarly myocardial infarctionmedicineAnimalsHumans030216 legal & forensic medicineMyocardial infarctionEarly myocardial infarction; Immunohistochemistry; Sudden cardiac death; Systematic review; Animals; Biomarkers; Death Sudden Cardiac; Forensic Pathology; Humans; Immunohistochemistry; Myocardial Infarction; 2734Forensic PathologyPostmortem DiagnosisAnimalbusiness.industryEarly myocardial infarction Immunohistochemistry Sudden cardiac Death Systematic reviewBiomarkermedicine.diseaseImmunohistochemistrySudden cardiac deathDeath Sudden CardiacHeart failureInclusion and exclusion criteriaSystematic reviewImmunohistochemistrybusinessBiomarkersHumanInternational Journal of Legal Medicine
researchProduct